Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis

Table 4 Independent predictors of fibrosis stage in 106 Italian patients with homozygous for the C282Y HFE mutation of hereditary hemochromatosis, at ordinal logistic regression analysis

	Estimate	Pvalue
Age (yr)	-0.03 ± 0.02	0.077
Gender (female)	-0.57 ± 0.26	0.029
BMI (kg/m2)	-0.08 ± 0.08	0.311
Diabetes	0.57 ± 0.34	0.09
ALT	-0.02 ± 0.008	0.013
GGT (IU/mL)	0.02 ± 0.01	0.035
Ferritin (ng/mL)	0.0001 ± 0.00	0.421
PNPLA3 genotype (per p.148M allele)	0.56 ± 0.27	0.041

BMI: Body mass index; ALT: Alanine aminotransaminase; GGT: γ-glutamyl transferase; p.148M: PNPLA3 rs738409 148Met protein variant.