Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis

Table 3 Independent predictors of aspartate aminotransferase and alanine aminotransaminase levels in 174 Italian patients with homozygous for the C282Y HFE mutation of hereditary hemochromatosis, in the multivariate generalized linear model

	AST			ALT
	Estimate	95% CI	Pvalue	Estimate	95% CI	Pvalue
Age (yr)	-0.27 ± 0.09	-0.45 - -0.09	0.0034	-0.55 ± 0.14	-0.81 - -0.27	0.0001
TS (%)	0.14 ± 0.07	-0.01 - 0.29	0.063	0.28 ± 0.11	0.05 - 0.50	0.016
Ferritin (ng/mL)	0.01 ± 0.001	0.008 - 0.012	< 0.0001	0.01 ± 0.001	0.009 - 0.014	< 0.0001
GGT (IU/mL)	0.10 ± 0.03	0.03 - 0.16	0.003	0.20 ± 0.05	0.10 - 0.29	< 0.0001
BMI (kg/m2)	0.86 ± 0.42	0.03 - 1.69	0.042	3.36 ± 0.63	2.12 - 4.60	< 0.0001
PNPLA3 genotype (per p.148M allele)	5.46 ± 1.68	2.15 - 8.67	0.0014	6.05 ± 2.51	1.09 - 11.00	0.017

AST: Aspartate aminotransferase; ALT: Alanine aminotransaminase; CI: Confidence interval; TS: Transferrin saturation; GGT: γ-glutamyl transferase; BMI: Body mass index; p.148M: PNPLA3 rs738409 148Met protein variant.