Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk

Table 2 Odds ratios and 95% confidence intervals for quartiles of each biomarker level and colorectal cancer risk from multivariate conditional logistic regression models¹

	For a change in 1SD	Quartile1	Quartile2	Quartile3	Quartile4
Adiponectin
OR	0.45	1 (ref)	0.83	0.42	0.11
95% CI	0.22-0.91		0.12-5.65	0.06-2.93	0.01-0.93
P for linear trend	0.03				0.03
Leptin
OR	0.55	1 (ref)	0.19	2.22	0.29
95% CI	0.21-1.40		0.02-1.9	0.25-20.09	0.02-3.65
P for linear trend	0.2				0.6
sVCAM-1
OR	1.69	1 (ref)	6.89	11.59	19.11
95% CI	0.96-2.98		0.72-66.4	0.64-209.81	1.4-261.27
P for linear trend	0.07				0.02
sICAM-1
OR	0.74	1 (ref)	0.38	0.07	0.13
95% CI	0.40-1.40		0.04-3.23	0.01-0.76	0.01-1.93
P for linear trend	0.4				0.08
sE-selectin
OR	0.95	1 (ref)	1.23	0.9	1.59
95% CI	0.49-1.81		0.13-11.49	0.1-8.14	0.16-15.62
P for linear trend	0.9				0.9
MCP-1
OR	1.35	1 (ref)	1.67	1.02	2.02
95% CI	0.73-2.49		0.27-10.24	0.17-6.24	0.26-15.97
P for linear trend	0.3				0.4
hs-CRP
OR	0.8	1 (ref)	0.73	2.22	1.53
95% CI	0.52-1.24		0.06-9.38	0.25-19.9	0.13-17.84
P for linear trend	0.3				0.6

¹Adjusted for age, sex, body mass index, intervention group, alcohol intake, physical activity, smoking status, family history of colorectal cancer, waist circumference, height and educational level. n = 50 colorectal cancer cases and 100 controls. Cut-offs for sex-specific quartiles were: hs-CRP: 0.6, 1.2, 2.3 in men and 0.5, 0.9, 2.1 in women; sICAM-1: 198.7, 242.0, 287.4 in men and 193.0, 232.5, 286.0 in women; sVCAM-1: 539.0, 653.5, 798.6 in men and 523.0, 651.5, 875.7 in women; sE-selectin: 29.8, 42.5, 51.7 in men and 26.0, 36.3, 44.6 in women; MCP-1: 216.7, 263.5, 316.5 in men and 171.0, 212.0, 238.0 in women; Leptin: 3.1, 5.0, 8.2 in men and 5.4, 9.6, 15.4 in women; Adiponectin: 4.2, 6.6, 10.0 in men and 9.5, 13.9, 16.0 in women. OR: Odds ratio; CI: Confidence interval; hs-CRP: Highly sensitive C-reactive protein; sICAM-1: Soluble intercellular adhesion molecule-1; sVCAM-1: Soluble vascular cell adhesion molecule-1; sE-selectin: Soluble E-selectin; MCP-1: Monocyte chemoattractant protein-1; ref: Reference category.