Evaluation of malignancy using Ki-67, p53, EGFR and COX-2 expressions in gastrointestinal stromal tumors

Table 2 Ki-67, P53, epidermal growth factor receptor, cyclooxygenase-2 expression related to clinicopathological features

Variable	Ki-67				P53				EGFR				COX-2
	0+	1+	2+	P value	0+	1+	2+	P value	0+	1+	2+	P value	0+	1+	2+	P value
Tumor size (cm)
≤ 2	6	1	0	0.02	3	3	1	0.47	1	3	3	0.41	2	2	3	0.07
> 2 to ≤ 5	21	7	1		8	14	7		6	12	11		17	7	5
> 5 to ≤ 10	15	15	4		9	10	15		11	8	15		20	9	5
> 10	9	10	7		5	11	10		9	4	13		21	1	4
Total	51	33	12		25	38	33		27	27	42		60	19	17
Mitotic rate (per 50 HPFs)
≤ 5	39	12	3	< 0.001	17	20	17	0.04	16	16	22	0.77	38	8	8	0.41
> 5 to ≤ 10	10	14	4		8	13	7		7	6	15		14	8	6
> 10	2	7	5		0	5	9		4	5	5		8	3	3
Risk of malignancy
Very low + low risk	23	4	0	< 0.001	9	11	7	0.04	6	11	10	0.56	17	6	4	0.50
Intermediate risk	13	9	2		9	11	4		7	5	12		12	5	7
High risk	15	20	10		7	16	22		14	11	20		31	8	6

EGFR: Epidermal growth factor receptor; COX-2: Cyclooxygenase-2; HPFs: High-power fields.