Role of genetics in the diagnosis and prognosis of Crohn's disease

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2012; 18(2): 105-118
Published online Jan 14, 2012. doi: 10.3748/wjg.v18.i2.105

Table 2 Predicted future developments in the genetics of Crohn's disease

What lies ahead in the genetics of Crohn’s disease

Gene-to-gene crosstalk and epistasis

Genome wide association studies

Microarrays

Fine single nucleotide polymorphism analysis

Genetic consortium studies and genome wide scans

Genome-wide association studies

Genetic consortium studies

Future perspectives

Functional studies to understand the mechanisms

Combining genetic data with functional data

Combination of a panel of clinical, biochemical, serological and genetic factors

Functional consequences of polymorphisms

Molecular and cellular mechanisms leading to Crohn's disease

Predict disease outcomes

Redesigning the methods of treatment

Citation: Tsianos EV, Katsanos KH, Tsianos VE. Role of genetics in the diagnosis and prognosis of Crohn's disease. World J Gastroenterol 2012; 18(2): 105-118
URL: https://www.wjgnet.com/1007-9327/full/v18/i2/105.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i2.105

Tsianos EV, Katsanos KH, Tsianos VE. Role of genetics in the diagnosis and prognosis of Crohn's disease. World J Gastroenterol 2012; 18(2): 105-118 [PMID: 22253516 DOI: 10.3748/wjg.v18.i2.105]

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