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Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 14, 2012; 18(2): 105-118
Published online Jan 14, 2012. doi: 10.3748/wjg.v18.i2.105
Table 1 Genetic polymorphisms related to Crohn's disease
Genes and the diagnosis of Crohn’s disease
Genes related to innate pattern recognition receptors
NOD2/CARD15
OCTN
TLR
Genes related to epithelial barrier homeostasis
IBD5
DLG5
Genes related to molecular mimicry and autophagy
ATG16L1
IRGM
LRRK2
Genes related to lymphocyte differentiation
IL23R
STAT3
Genes related to secondary immune response and apoptosis
MHC
HLA
Genes and the prognosis of Crohn’s disease
Genes related to age of Crohn’s disease onset
TNFRSF6B, CXCL9, IL23R, NOD2 , ATG16L1, CNR1, IL-10, MDR1, DLG5, IRGM
Genes related to Crohn’s disease behaviour
Stenotic/structuring behaviour:NOD2, TLR4, IL-12B, CX3CR1, IL-10, IL-6
Penetrating/fistulizing behaviour:NOD2, IRGM, TNF, HLADRB1, CDKAL1
Inflammatory behaviour:HLA
Granulomatous disease:TLR4/CARD15
Genes related to Crohn’s disease location
Upper gastrointestinal:NOD2, MIF
Ileal:IL-10, CRP, NOD2, ZNF365, STAT3
Ileocolonic:ATG16L1, TCF-4 (TCF7L2)
Colonic:HLA, TLR4, TLR1, -2, -6
Genes related to Crohn’s disease activity
HSP70-2, NOD2, PAI-1, CNR1
Genes related to surgery
NOD2 , HLA-G
Genes related to dysplasia and cancer
FHIT
Genes related to extraintestinal manifestations
CARD15, FcRL3, HLADRB*103, HLAB*27 HLA-B*44, HLA-B*35, TNFa-308A, TNF-1031C, STAT3
Pharmacogenetics in Crohn’s disease
CARD15, NAT, TPMT, MDR1, MIF, DLG5, TNF, LTA