Clinical significance of connective tissue growth factor in hepatitis B virus-induced hepatic fibrosis

Figure 1 Production of connective tissue growth factor or transforming growth factor β-1 in fibrous septa of hepatitis B virus-infected livers. Connective tissue growth factor mRNA (A) or protein (B) were detected by in situ hybridization (ISH) or immunohistochemistry respectively. transforming growth factor β-1 mRNA (C) was detected by ISH while collagen bundles (D) were stained red using Van Gieson’s method. Original magnification, × 200 in A, B, C and D. Examples of positively stained cells or structures in each panel are arrowed.