Pathogenesis of NSAID-induced gastric damage: Importance of cyclooxygenase inhibition and gastric hypermotility

Figure 14 Effects of aspirin and salicylic acid on gastric lesions (A) and gastric hypermotility (B) caused by indomethacin in rats. A: The animals were given indomethacin (35 mg/kg) s.c., and killed 24 h later. Aspirin (20-200 mg/kg) or salicylic acid (17.8-178 mg/kg) was given s.c. 30 min before indomethacin. Data are presented as the mean ± SE in 4-6 rats. ^aP < 0.05 vs control; B: Animals were given indomethacin (30 mg/kg) s.c. and subsequently aspirin (200 mg/kg) or salicylic acid (178 mg/kg) s.c. 2 h later. Note that both aspirin and salicylic acid markedly inhibited the intestinal hypermotility induced by indomethacin, with the effect of salicylic acid appearing much earlier than that of aspirin (data from ref. 25 after modification).