Pathogenesis of NSAID-induced gastric damage: Importance of cyclooxygenase inhibition and gastric hypermotility

Figure 6 Effects of various prostaglandin E agonists on gastric lesions generated by indomethacin in rats. The animals were given indomethacin (30 mg/kg) s.c. and killed 4 h later. Prostaglandin E₂ (PGE₂, 0.3 mg/kg), 17-phenyl PGE₂ (0.3 mg/kg; EP1 agonist), sulprostone (0.3 mg/kg; EP1/EP3 agonist), butaprost (10 mg/kg; EP2 agonist), ONO-NT-012 (10 mg/kg; EP3 agonist) and 11-deoxy PGE₁ (3 mg/kg; EP3/EP4 agonist) were given i.v. 10 min before indomethacin. Data are presented as the mean ± SE in 4-6 rats. ^aP < 0.05 vs control (data from ref. 39 after modification).