Protective effects of 5-methoxypsoralen against acetaminophen-induced hepatotoxicity in mice

Table 1 Effects of acetaminophen alone, 5-methoxypsoralen multi-dose and 5-methoxypsoralen alone on alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase activities, hepatic malondialdehyde and reduced glutathione/oxidized glutathione ratio in mice (mean ± SE)

Treatments groups	ALT (IU/L)	AST (IU/L)	LDH (IU/L)	MDA (nmol/mg)	GSH/GSSH
Vehicle control	30 ± 21	146 ± 58	1504 ± 410	0.18 ± 0.11	6.045 ± 0.629
APAP alone at 500 mg/kg	8355 ± 3940a	6482 ± 4018a	24 627 ± 10975a	2.15 ± 1.07a	3.306 ± 0.282a
5-MOP at 12.5 mg/kg	1674 ± 1810c	729 ± 685c	7220 ± 6317c	0.98 ± 0.45	3.834 ± 0.340
5-MOP at 25 mg/kg	54 ± 39c	187 ± 149c	1618 ± 719c	0.59 ± 0.07c	5.330 ± 0.421c
5-MOP at 50 mg/kg	19 ± 9c	141 ± 12c	1394 ± 469c	0.47 ± 0.06c	6.180 ± 0.212c
5-MOP alone at 50 mg/kg	37 ± 20	138 ± 22	1471 ± 191	0.15 ± 0.09	6.858 ± 0.678

^aP < 0.05 vs vehicle control group;

^cP < 0.05 vs acetaminophen (APAP) alone group. 5-MOP: 5-methoxypsoralen; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; LDH: Lactate dehydrogenase; MDA: Malondialdehyde; GSH: Reduced glutathione; GSSG: Oxidized glutathione.