Prognostic significance of PTEN, Ki-67 and CD44s expression patterns in gastrointestinal stromal tumors

Table 3 Univariate and multivariate COX regression analyses of molecular markers in gastric gastrointestinal and small intestinal stromal tumor

	Univariate analysis		Multivariate analysis
	OR (95% CI)	P value	OR (95% CI)	P value
Gastric GIST
PTEN	0.23 (0.07-0.74)	0.013	0.35 (0.10-1.20)	0.100
Ki-67	4.54 (1.45-14.16)	0.009	2.69 (0.73-9.87)	0.130
CD44s	0.21 (0.07-0.73)	0.013	0.43 (0.83-9.98)	0.320
PTEN, Ki-67, CD44s	5.92 (1.29-27.08)	0.022	1.35 (0.15-11.80)	0.780
MMP-9	4.22 (1.92-19.31)	0.042
TIMP-1	0.90 (0.29-2.82)	0.862
MMP-9/TIMP-1	0.72 (0.22-2.38)	0.586
Small intestinal GIST
Ki-67	3.29 (1.14-9.46)	0.019
PTEN, Ki-67	4.02 (1.25-16.09)	0.021

MMP: Matrix metalloproteinase; GIST: Gastrointestinal stromal tumor; OR: Odds ratio.