Second-line therapy for gemcitabine-pretreated advanced or metastatic pancreatic cancer

Table 2 Treatment regimens in second line n (%)

Groups of chemotherapy	Patients
Cisplatin group	23 (28.8)
LV5FU2-CDDP	23 (28.8)
Irinotecan group	22 (27.5)
FOLFIRI	12 (15.0)
XELIRI	10 (12.5)
Oxaliplatin group	21 (26.2)
GEMOX	13 (16.2)
FOLFOX	8 (10.0)
Other group	14 (17.5)
5-FU alone	3 (3.7)
Gemcitabine + erlotinib	4 (5.0)
Gemcitabine + capecitabine	3 (3.7)
Capecitabine	1 (1.2)
5-FU + CDDP + RT	3 (3.7)

LV5FU2-CDDP: Folinic acid 400 mg/m², 5-FU bolus 400 mg/m², 5-FU 2400 mg/m² over 46 h and cisplatin 50 mg/m² on day 2, every 2 wk; FOLFIRI: Irinotecan 180 mg/m², folinic acid 400 mg/m², 5-FU bolus 400 mg/m², 5-FU 2400 mg/m² over 46 h, every 2 wk; XELIRI: Irinotecan 240 mg/m² and capecitabine po 2000 mg/m² J2-J15 every 3 wk; GEMOX: Gemcitabine 1000 mg/m² J1 and oxaliplatine 100 mg/m² J2, every two weeks; FOLFOX: Oxaliplatine 85 mg/m², folinic acid 400 mg/m², 5-FU bolus 400 mg/m², 5-FU 2400 mg/m² over 46 h, every 2 wk; 5-FU alone: 5-FU 250 mg/m² every day as continuous infusion; Gemcitabine + erlotinib: Gemcitabine 1000 mg/m² weekly X 7 for 8 wk then weekly X 3 out of 4 wk plus either erlotinib 100 mg po daily; Gemcitabine + capecitabine: Gemcitabine 1000 mg/m² weekly X 3 for 4 wk and capecitabine 1600 mg/m² J1-J21; Gapecitabine: 2500 mg/m² weekly X 2 for 3 wk; 5-FU + CDDP + RT: 60 Gy in 6 wk, 2 Gy/fraction, concomitant with 5-FU 300 mg/m² per 24 h as a continuous infusion, day 1-5 every week and cisplatin 20 mg/m² per day, day 1-5 at week 1 and 5.