CCL7 and CCL21 overexpression in gastric cancer is associated with lymph node metastasis and poor prognosis

Table 2 Univariate analysis of the clinicopathologic parameters influencing the disease-free survival of 194 gastric cancer patients undergoing gastrectomy

Factors	Cases	Mean survival (mo)	95% CI of mean	5-year survival (%)	P value
Age (yr)
≤ 60	83	57.33	50.22-64.44	60.2	0.516
> 60	111	53.34	46.93-59.76	56.1
Gender
Male	114	57.90	51.74-64.05	62.2	0.174
Female	80	51.09	43.61-58.56	51.7
Type of gastrectomy
Total	41	31.85	23.28-40.43	33.5	< 0.0001
Subtotal	153	60.21	55.14-65.48	64.5
Tumor location
Upper	22	26.01	15.81-36.21	27.3	< 0.0001
Middle	40	69.22	61.15-71.29	77.0
Lower	124	56.56	50.70-62.43	59.5
Diffuse	8	23.41	7.46-39.36	25.0
Margin
Negative	173	57.71	52.73-62.68	62.3	0.0001
Positive	21	27.41	17.26-37.56	12.6
Tumor size (cm)
≤ 3	95	70.94	65.97-75.92	80.7	< 0.0001
> 3	99	39.02	32.23-45.81	34.6
Differentiation
Well	18	65.58	59.43-71.73	94.4	< 0.0001
Moderate	55	43.11	35.16-51.06	54.4
Poor	52	37.91	30.28-45.54	33.6
Signet ring cell	69	62.16	54.89-69.43	67.9
Depth of invasion
T1	47	79.53	75.46-83.60	95.7	< 0.0001
T2	37	71.92	64.56-79.28	80.6
T3	101	40.04	33.53-46.54	35.4
T4	9	10.57	5.94-15.21	0.0
Lymph node metastasis
N0	88	73.64	69.17-78.11	83.8	< 0.0001
N1	47	57.67	47.75-67.59	64.9
N2	23	31.61	21.57-41.65	23.9
N3	36	15.39	10.83-19.95	0.0
Vascular invasion
No	168	60.36	55.48-65.23	65.4	< 0.0001
Yes	26	17.74	11.39-24.08	4.4
Lymphatic invasion
No	104	70.58	65.84-75.33	79.2	< 0.0001
Yes	90	36.48	29.43-43.53	32.1
Perineural invasion
No	109	67.57	62.27-72.88	76.3	< 0.0001
Yes	84	37.36	30.70-44.02	34.1
Desmoplastic reaction
None	28	67.55	56.87-78.24	78.6	< 0.0001
Mild	64	70.20	64.03-76.37	78.7
Moderate	75	41.99	34.35-49.62	38.8
Marked	27	36.67	24.49-48.85	36.7
TNM stage
I	64	78.86	75.66-82.07	92.1	< 0.0001
II	44	66.55	58.17-74.92	74.2
III	38	46.52	36.06-56.98	45.7
IV	48	14.71	10.94-18.48	0.0
CCL-7
Higher	82	45.62	37.97-53.28	43.6	0.002
Equal	69	60.09	52.62-67.57	64.7
Lower	43	63.28	54.24-72.32	71.8
CCL-8
Higher	58	51.05	42.41-59.70	50.0	0.269
Equal	64	51.89	43.39-60.39	57.4
Lower	72	59.97	52.60-67.34	64.6
CCL-21
Higher	87	44.96	37.83-52.10	45.8	0.001
Equal	63	56.60	48.30-64.90	59.5
Lower	44	70.58	63.24-77.93	79.2

CCL: Chemokine ligand; TNM: Tumor node metastasis.