CCL7 and CCL21 overexpression in gastric cancer is associated with lymph node metastasis and poor prognosis

Table 1 Association of chemokine ligand 7, chemokine ligand 8 and chemokine ligand 21 expression with the clinicopathologic parameters

Factors	Cases	CCL-7 expression				CCL-8 expression				CCL-21 expression
		Higher	Equal	Lower	P value	Higher	Equal	Lower	P value	Higher	Equal	Lower	P value
		n = 82	n = 69	n = 43		n = 58	n = 64	n = 72		n = 87	n = 63	n = 44
Age (yr)
≤ 60	83	31	31	21	0.449	17	28	38	0.026	34	24	25	0.101
> 60	111	51	38	22		41	36	34		53	39	19
Gender
Male	114	52	40	22	0.412	36	40	38	0.429	47	45	22	0.041
Female	80	30	29	21		22	24	34		40	18	22
Tumor location
Upper	22	10	6	6	0.025	4	6	12	0.004	8	9	5	0.026
Middle	40	10	17	13		10	6	24		13	11	16
Lower	124	58	46	20		42	48	34		60	43	21
Whole	8	4	0	4		2	4	2		6	0	2
Tumor size (cm)
≤ 3	95	29	36	30	0.001	24	28	43	0.068	34	35	26	0.043
> 3	99	53	33	13		34	36	29		53	28	18
Differentiation
Well	18	6	8	4	0.177	5	6	7	0.422	7	7	4	0.130
Moderate	55	27	22	6		17	23	15		30	18	7
Poor	52	25	15	12		19	13	20		27	12	13
Signet ring cell	69	24	24	21		17	22	30		23	26	20
Depth of wall invasion
T1	47	12	19	16	0.001	8	15	24	0.070	9	18	20	< 0.0001
T2	37	8	18	11		13	12	12		9	18	10
T3	101	58	29	14		35	31	35		64	24	13
T4	9	4	3	2		2	6	1		5	3	1
Lymph node metastasis
N0	88	30	36	22	0.020	21	29	38	0.488	28	33	27	0.003
N1	47	16	16	15		16	17	14		20	17	10
N2	23	13	7	3		7	6	10		13	5	5
N3	36	23	10	3		14	12	10		26	8	2
Vascular invasion
No	168	70	60	38	0.800	50	58	60	0.561	71	57	40	0.163
Yes	26	12	9	5		8	6	12		16	6	4
Lymphatic invasion
No	104	37	39	28	0.086	27	34	43	0.325	36	38	30	0.006
Yes	90	45	30	15		31	30	29		51	25	14
Desmoplastic reaction
None	28	6	14	8	0.006	5	6	17	0.071	7	9	12	< 0.0001
Mild	64	22	20	22		18	21	25		17	26	21
Moderate	75	43	25	7		23	30	22		44	24	7
Marked	27	11	10	6		12	7	8		19	4	43
TNM stage
I	64	16	27	21	0.008	14	20	30	0.427	13	26	25	< 0.0001
II	44	17	17	10		13	14	17		18	18	8
III	38	20	12	6		13	14	11		24	8	6
IV	48	29	13	6		18	16	14		32	11	5

CCL: Chemokine ligand; TNM: Tumor node metastasis.