Increased numbers of Foxp3-positive regulatory T cells in gastritis, peptic ulcer and gastric adenocarcinoma

Figure 1 Immunohistochemistry of CD25, CD4, and Foxp3 in healthy controls, acute gastritis, chronic gastritis, intestinal metaplasia, and gastric cancer (original magnification, 400 ×). Immunohistochemistry of CD25 (left), CD4 (middle), and Foxp3 (right) in gastric mucosa from A: Healthy controls; B: Acute gastritis; C: Chronic gastritis; D: Intestinal metaplasia; E: Gastric cancer. CD4 and CD25 staining (brown) were found on the surface of T lymphocytes, and Foxp3 staining (brown) was located in the nucleus of T lymphocytes in lamina propria around glands.