Strong expression of CD133 is associated with increased cholangiocarcinoma progression

Table 1 Relation between clinicopathological features and immunohistochemical staining of CD133 in cholangiocarcinoma specimens

Variable	Total(n = 34)	CD133 expression		P-value
		Weak	Strong
Age
< 60	18	7	11	0.477
> 60	16	4	12
Sex
Male	22	8	14	0.705
Female	12	3	9
Tumor differentiation
Well	17	7	10	0.465
Moderate/poor	17	4	13
Node
Negative	16	9	7	0.0091
Positive	18	2	16
Distant metastasis
Negative	24	10	14	0.113
Positive	10	1	9
Surgical resection margin2
R0	20	10	10	0.0111
R1, R2	14	1	13
Location of tumor
Perihilar	12	3	9	0.705
Intrahepatic	22	8	14
Neurovascular invasion3
Positive	15	8	7	0.210
Negative	9	2	7

¹Statistically significant;

²Surgical resection margin: R0 = negative resection margin, R1 = microscopic positive resection margin and R2 = macroscopic positive resection margin;

³To study the presence of neurovascular invasion, we excluded 10 specimens derived from tissue biopsy.