Body mass index is associated with age-at-onset of HCV-infected hepatocellular carcinoma patients

Table 2 Analysis of factors affecting development of hepatocellular carcinoma at younger age (under 60 yr old)

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI	P	HR	95% CI	P
Sex
Female	1			1
Male	5.43	2.647-11.120	< 0.0001	3.58	1.580-8.133	0.002
BMI
< 25	1			1
≥ 25	1.73	1.044-2.851	0.033	1.82	1.015-3.270	0.045
Diabetes mellitus
Without	1			1
With	1.12	0.619-2.037	0.703	1.00	0.516-1.952	0.991
Smoking (packs year)
< 20	1			1
≥ 20	2.71	1.669-4.393	< 0.0001	1.64	1.904-2.991	0.104
Alcohol (g/d)
< 60	1			1
≥ 60	3.89	1.926-7.874	0.0002	2.51	1.130-5.563	0.024
Total bilirubin (mg/dL)
< 2.0	1			1
≥ 2.0	2.23	1.003-4.958	0.049	2.33	0.898-6.033	0.082
Prothrombin activity (%)
≥ 70	1			1
< 70	1.91	1.111-3.262	0.019	1.60	0.859-2.987	0.139
Platelet (× 104/μL)
≥ 10	1			1
< 10	1.34	0.829-2.166	0.232	1.60	0.877-2.886	0.118
ALT (IU/L)
< 80	1			1
≥ 80	1.44	0.884-2.350	0.142	1.17	0.656-2.090	0.542
GGT (IU/L)
< 50	1			1
≥ 50	3.24	1.731-6.053	0.0002	2.38	1.194-4.727	0.014

HR: Hazard ratio; BMI: Body mass index; ALT: Alanine aminotransferase; GGT: γ-glutamyl transpeptidase.