Clinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients

Table 4 Correlation between K-ras mutations and clinicopathological factors in colorectal cancer n (%)

Terms	All	Wild type	Mutation type	P value
No. of patients	118	77 (65.3)	41 (34.7)
Gender				0.037
Male	71	51 (71.8)	20 (28.2)
Female	47	26 (55.3)	21 (44.7)
Median age (yr)	61.0	64.0	60.0	0.728
Males	65.0	65.0	65.5
Females	60.0	60.5	58.0
Colorectal segment				0.559
Cecum	5	1 (20.0)	4 (80.0)
Ascending colon	23	17 (73.9)	6 (26.1)
Transversal colon	8	4 (50.0)	4 (50.0)
Descending colon	5	4 (80.0)	1 (20.0)
Sigmoid	25	16 (64.0)	9 (36.0)
Rectum	52	35 (67.3)	17 (32.7)
Differentiation				0.761
Poor	17	12 (70.6)	5 (29.4)
Moderate	42	25 (59.5)	17 (40.5)
Well	59	40 (67.8)	19 (32.2)
UICC classification				0.631
I	18	9 (50.0)	9 (50.0)
II	48	37 (77.1)	11 (22.9)
III	37	23 (62.2)	14 (37.8)
IV	15	8 (53.3)	7 (46.7)
Bowel wall invasion (pT)				0.120
pT1	2	1 (50.0)	1 (50.0)
pT2	21	11 (52.4)	10 (47.6)
pT3	65	43 (66.2)	22 (33.8)
pT4	30	22 (73.3)	8 (26.7)
Lymph node metastasis (pN)				0.585
pN0	69	47 (68.1)	22 (31.9)
pN1-2	49	31 (63.3)	18 (36.7)
Distant metastasis (pM)				0.301
pM0	103	70 (68.0)	33 (32.0)
pM1	15	8 (53.3)	7 (46.7)

UICC: Union for International Cancer Control.