N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer

doi:10.3748/wjg.v17.i6.760

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Feb 14, 2011; 17(6): 760-765
Published online Feb 14, 2011. doi: 10.3748/wjg.v17.i6.760

Table 4 Correlation between genotypes and risk for cancer in smokers or ex-smokers

Genetic polymorphism	Cancer, n (%)	Control, n (%)	P	OR (95% CI)
NAT2^a
All	65	87
Mx/Mx	40 (61.5)	39 (44.8)	0.09	1
W/Mx	22 (33.8)	39 (44.8)		1.82 (0.92-3.60)
W/W	3 (4.6)	9 (10.3)		3.08 (0.77-12.22)
Slow	40 (61.5)	39 (44.8)	0.06	1.97 (1.02-3.79)
Fast	25 (38.5)	48 (61.0)

^aHomozygous individuals with genotype W/W, and heterozygote W/Mx, are grouped into fast acetylation phenotype, while homozygous Mx/Mx are grouped in slow acetylators. NAT2: N-acetyltransferase 2; OR: Odds ratio; 95% CI: Confidence interval.

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Citation: Silva TDD, Felipe AV, Lima JM, Oshima CTF, Forones NM. N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer. World J Gastroenterol 2011; 17(6): 760-765
URL: https://www.wjgnet.com/1007-9327/full/v17/i6/760.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i6.760

Silva TDD, Felipe AV, Lima JM, Oshima CTF, Forones NM. N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer. World J Gastroenterol 2011; 17(6): 760-765 [PMID: 21390146 DOI: 10.3748/wjg.v17.i6.760]

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