Perinatal and early life risk factors for inflammatory bowel disease

Table 2 Associations between maternal characteristics and inflammatory bowel disease in the child

Maternal characteristics	No. of births	Crohn’s disease			Ulcerative colitis
		No. of cases	Percent	P-value1	No. of cases	Percent	P-value2
Maternal age (yr)				0.19			0.90
14-24	86 544	41	0.047%		21	0.024%
25-34	142 939	59	0.041%		40	0.028%
35-49	18 852	14	0.074%		5	0.027%
Maternal Crohn’s disease or ulcerative colitis				0.011a			1.00
No	248 132	112	0.045%		66	0.027%
Yes	530	2	0.380%		0
Maternal social class				0.10			0.12
I & II	68 244	21	0.031%		12	0.018%
III	86 869	54	0.062%		32	0.037%
IV & V	35 510	22	0.062%		11	0.031%
Marital status				0.081			0.042a
Married	224 261	109	0.049%		65	0.029%
Not married	23 939	5	0.021%		1	0.004%
Maternal smoking during pregnancy				0.054			0.73
No	110 961	27	0.024%		18	0.016%
Yes	34 245	16	0.047%		4	0.012%
Maternal ABO blood group				0.84			0.81
A	101 010	44	0.044%		26	0.026%
O	105 391	49	0.046%		30	0.028%
Maternal rhesus Status				0.96			0.97
Negative	39 805	18	0.045%		10	0.025%
Positive	196 652	87	0.044%		53	0.027%
Pre-eclampsia				0.29			1.00
No	224 360	99	0.044%		60	0.027%
Yes	24 250	15	0.062%		6	0.025%
Parity				0.23			0.59
O	104 210	41	0.039%		25	0.024%
1+	144 214	73	0.051%		41	0.028%

^1,2P-values obtained through χ² tests, with Yates continuity corrections;

¹Comparing those with Crohn’s disease with those without known inflammatory bowel disease (IBD);

²Comparing those with ulcerative colitis with those without known IBD.

^aP < 0.05.