Recent advances in cytokines: Therapeutic implications for inflammatory bowel diseases

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Feb 7, 2011 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 7, 2011; 17(5): 547-556
Published online Feb 7, 2011. doi: 10.3748/wjg.v17.i5.547

Table 1 Clinical efficacy and marketing approval for anti-tumor necrosis factor-α agents

Drug name	Efficacy (% of induction of remission/% sustained remission)			Approved (FDA/Europe)
Drug name	Luminal CD	Fistulizing CD	UC	Luminal CD	Fistulizing CD	UC
Infliximab (Remicade^®)	33/45	55/36	38.8/23.1	Yes/Yes	Yes/Yes	Yes/Yes
Adalimumab (Humira^®)	36/36	No RCT	No RCT	Yes/Yes	No/No	No/No
Certolizumab (Cimzia^®)	35/48	No RCT	No RCT	Yes/No	No/No	No/No

CD: Crohn’s disease; UC: Ulcerative colitis; FDA: US food and drug administration; RCT: Randomized controlled trial.

Citation: Bouguen G, Chevaux JB, Peyrin-Biroulet L. Recent advances in cytokines: Therapeutic implications for inflammatory bowel diseases. World J Gastroenterol 2011; 17(5): 547-556
URL: https://www.wjgnet.com/1007-9327/full/v17/i5/547.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i5.547