Decreased hepatic peroxisome proliferator-activated receptor-γ contributes to increased sensitivity to endotoxin in obstructive jaundice

Figure 3 Effects of pretreatment with rosiglitazone (3 mg/kg, i. p.) on survival rates in rats after administration of lipopolysaccharide (6 mg/kg for sham-group and 3 mg/kg for bile duct ligation group, i.p.). The survival curve was estimated by the Kaplan-Meier method and the log-rank method was applied to compare differences in survival rates between groups (n = 20). Rosiglitazone pretreatment significantly improve the survival in sham + lipopolysaccharide (LPS) (6 mg/kg) group but not in bile duct ligation + LPS (3 mg/kg) group, ^aP < 0.05 vs sham + LPS group. BDL : Bile duct ligation; ROSI: Rosiglitazone.