Mutations around interferon sensitivity-determining region: A pilot resistance report of hepatitis C virus 1b in a Hong Kong population

Table 1 Amino acid variations within extended interferon sensitivity-determining region of hepatitis C virus 1b

Locus	Amino acid variations		mid-P	Prediction
	IFN-NR (n = 18)	IFN-SVR (n = 19)		Sensitivity (%)	Specificity (%)
2146	T (10/18, 55.6%)	T (15/19, 78.9%)	0.085
	V (4/18, 22.2%)	V (2/19, 10.5%)	0.20
	A (4/18, 22.2%)	A (1/19, 5.3%)	0.09
		M (1/19, 5.3%)	-
2169	A (16/18, 88.9%)	A (13/19, 68.9%)	0.12
	T (2/18, 11.1%)	T (6/19, 31.6%)	0.12
2260	R (18/18, 100%)	R (15/19, 78.9%)	0.05
	H (0/18, 0%)	H (4/19, 21.1%)	0.05	100	21.1
2268	V (14/18, 77.8%)	V (18/19, 100%)	0.09
	I (4/18, 22.2%)	I (0/19, 0%)	0.023	22.2	100
		M (1/19, 5.3%)	-
2278	S (17/18, 94.4%)	S (14/19, 73.7%)	0.09
	T (0/18, 0%)	T (4/19, 21.1%)	0.05	100	21.1
	P (1/18, 5.6%)	H (1/19, 5.3%)	-
2285	L (14/18, 77.8%)	L (10/19, 52.6%)	0.085
	M (4/18, 22.2%)	M (9/19, 47.4%)	0.085

Locus position refers to the amino acid position in hepatitis C virus-J. P values were calculated by two-tailed Fisher's exact test (mid-P). "-" in the column of "P" means no P value calculated for this rare amino acid in that position. Sensitivity and specificity were calculated for the amino acid variations associated with treatment outcome. IFN: Interferon; NR: Non-response; SVR: Sustained virological response.