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©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 28, 2011; 17(48): 5246-5259
Published online Dec 28, 2011. doi: 10.3748/wjg.v17.i48.5246
Table 2 Predicted future developments in the genetics of Crohn’s disease
What lies ahead in the genetics of crohn’s disease
Gene-to-gene crosstalk and epistasis
Genome-wide association studies
Microarrays
Fine single nucleotide polymorphism analysis
Genetic consortium studies and genome-wide scans
Genome-wide association studies
Genetic consortium studies
Future perspectives
Functional studies to understand the mechanisms
Combining genetic data with functional data
Combination of a panel of clinical, biochemical, serological and genetic factors
Functional consequences of polymorphisms
Molecular and cellular mechanisms leading to Crohn’s disease
Predict disease outcomes
Redesigning the methods of treatment


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