Helicobacter pylori's virulence and infection persistence define pre-eclampsia complicated by fetal growth retardation

Table 6 Hematological values and cytotoxin-associated antigen A/vacuolating cytotoxin A antigens

Variables	Normal values in Italian female population range	CagA-VacA- (n = 45) Median (25th-75th)	CagA-VacA+ (n =10) Median (25th-75th)	CagA+VacA- (n = 3) Median (25th-75th)	CagA+VacA+ (n = 53) Median (25th-75th)	P value2
Total leukocyte count (1 × 103/μL)	4.00-11.00	12.02 (10.6-13.13)3	8.95 (7.75-10.5)356	14.1 (12.4-16.34)5	11.27 (9.62-13.64)6	30.003; 60.012; 50.014
Neutrophils (1 × 103/μL)		10.02 (8.88-11.40)	7.45 (4.87-9.48)	12.75 (11.03-14.48)	8.43 (6.9-10.5)	NS
(%)	45.0-73.0	78.8 (67.05-88.85)	71.9 (68.1-77.3)	83.4 (78.2-88.6)	72.05 (67.4-80)	NS
Lymphocytes (1 × 103/μL)		1.72 (1.11-2.85)	2.13 (1.68-2.13)	1.61 (0.93-2.28)	2.34 (1.63-3.07)	NS
(%)	19.0-47.0	15.3 (8.9-23.2)	20.6 (17.4-23.5)	10.95 (5.7-16.2)	18.75 (14-23.3)	NS
Monocytes (1 × 103/μL)		0.57 (0.26-0.89)	0.54 (0.43-0.6)	0.78 (0.68-0.88)	0.6 (0.44-0.84)	NS
(%)	3.0-9.0	4.75 (2.15-6.85)	5.2 (4.9-6)	5.1 (4.8-5.4)	5.81 (4.3-7.4)	NS
Eosinophils (1 × 103/μL)		0.05 (0.02-0.18)	0.09 (0.03-0.21)	0.06 (0.03-0.08)	0.06 (0.03-0.15)	NS
(%)	0.2-4.4	0.55 (0.1-1.45)	1.2 (0.2-2)	0.4 (0.2-0.6)	0.58 (0.3-1.17)	NS
Basophils (1 × 103/μL)		0.01 (0-0.02)	0.03 (0.01-0.03)	0.02 (0.02-0.03)	0.03 (0.01-0.04)	NS
(%)	0.1-1.3	0.1 (0-0.2)	0.2 (0.2-0.3)	0.15 (0.1-0.2)	0.2 (0.2-0.3)	0.002
Platelets1 (1 × 103/μL)	150-400	222 (169-249)	175 (154-209.5)	214 (210-228)	191 (166-242)	NS
ALT1 (U/L)	< 34	16 (12.5-26)4	11 (9-12)5	32 (30-178)457	17 (11.5-24)7	40.020; 50.025; 70.023
AST1 (U/L)	< 31	18 (15.5-23.5)	13 (12-19)	58 (15-143)	18 (14.5-26)	NS

¹Hemolysis-elevated liver enzymes-low platelets cases excluded;

²P values were calculated by non-parametric Kruskal-Wallis H test, with post-hoc analysis by Mann-Whitney U test;

³Comparison between CagA-VacA- and CagA-VacA+ groups;

⁴Comparison between CagA-VacA- and CagA+VacA- groups;

⁵Comparison between CagA-VacA+ and CagA+VacA- groups;

⁶Comparison between CagA-VacA+ and CagA+VacA+ groups;

⁷Comparison between CagA+VacA- and CagA+VacA+ groups. CagA: Cytotoxin-associated antigen A; VacA: Vacuolating cytotoxin A; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; NS: Non significant.