Superiority of metastatic lymph node ratio to the 7th edition UICC N staging in gastric cancer

Table 1 Univariate analysis of various clinicopathologic factors in 1042 cases of gastric cancer

Variable	n (%)	5-yr survival rate (%)	Log rankχ2value	Hazardratio	P value
Gender			0.433	1.060	0.511
Male	708 (67.9)	48.6
Female	334 (32.1)	45.1
Age (continuous)	1042 (100)	47.5	124.704	1.019	< 0.001
Tumor location			78.529	0.735	< 0.001
Proximal	579 (55.6)	39.0
Distal	418 (40.1)	62.0
Two-thirds or more	45 (4.3)	17.5
Tumor size (continuous)		47.5	124.704	1.147	< 0.001
Histological grade			18.407	1.254	< 0.001
Well/moderately differentiated adenocarcinoma	388 (37.2)	54.8
Poorly differentiated adenocarcinoma	448 (43.0)	44.7
Undifferentiated adenocarcinoma/signet-ring cell carcinoma/mucinous adenocarcinoma	206 (19.8)	39.8
Lymphatic/venous invasion			65.905	2.685	< 0.001
No	954 (91.6)	50.0
Yes	88 (8.4)	20.4
Depth of invasion (7th edition)			172.456	1.852	< 0.001
T1	81 (7.8)	90.7
T2	120 (11.5)	74.3
T3	195 (18.7)	57.5
T4a	538 (51.6)	35.9
T4b	108 (10.4)	22.1
The 7th edition UICC N			168.281	1.604	< 0.001
N0	332 (31.9)	71.1
N1	211 (20.2)	50.7
N2	268 (25.7)	37.5
N3	231 (22.2)	22.2
The 6th edition UICC N			160.982	1.571	< 0.001
N0	332 (31.9)	71.1
N1	479 (46.0)	43.3
N2	172 (16.5)	21.4
N3	59 (5.7)	25.1
Metastatic lymph node ratio			281.341	1.776	< 0.001
MLNR0	332 (31.9)	71.1
MLNR1	277 (26.6)	59.0
MLNR2	154 (14.8)	32.7
MLNR3	279 (26.8)	16.0
Retrieved lymph nodes			67.098	0.616	< 0.001
≤ 15	657 (63.1)	58.0
> 15	385 (36.9)	68.4