Prevention of peritoneal adhesions: A promising role for gene therapy

Table 1 In vivo adhesion prevention gene therapy studies

Ref.	Vector/dose	Nucleic acid	Adhesion reduction (%)
Atta et al[101]	Adenovirus, 5 × 107 pfu	tPA gene	34
Guo et al[102]	Plasmid, 100 μg, sonoporation	Smad7 gene	37
Guo et al[103]	Adenovirus	Sphingosine kinase-1 gene	62
Segura et al[31]	Polyethylenimine cationic polymer, 2-4 nmol	siRNA HIF-1α	36 to 52
		siRNA PAI-1
Liu et al[104]	Adenovirus, 1 × 109 pfu	HGF gene	56

tPA: Tissue plasminogen activator; siRNA: Small interfering RNA; HIF-1α: Hypoxia inducible factor-1α; PAI-1: Plasminogen activator inhibitors 1; HGF: Hepatocyte growth factor.