Genetic interactions and modifier genes in Hirschsprung's disease

Figure 1 Interactions between known Hirschsprung's disease associated genes and their modifiers. Confirmed and putative interactions are shown by the solid and dotted lines, respectively. Red: HSCR associated gene; Blue: Known HSCR modifier gene; Black: Modifier loci with unknown gene. The question mark represents a disparity in the existing data obtained from human clinical and animal studies. HSCR: Hirschsprung's disease; BBS: Bardet-Biedel syndrome.