Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation

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Dec 7, 2011 (publication date) through Sep 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2011; 17(45): 5007-5013
Published online Dec 7, 2011. doi: 10.3748/wjg.v17.i45.5007

Table 4 Prothrombin 20210 mutation rates in various “fibrosis rate” models

Rate of fibrosis	PT20210 mutation in slow fibrosers (%)	PT20210 mutation in fast fibrosers (%)	P value³
Rate of fibrosis by Poynard	5.50	13	0.18
0.13 units/yr¹	5.10	15.80	0.07
0.133 units/yr²	5	16.70	0.03

Various cut-offs of rate of fibrosis were employed on our cohort to differentiate between fast and slow fibrosers.

¹Rate of fibrosis according to Fishman et al[22];

²Rate of fibrosis according to Wright et al[10];

³P value calculated by Fisher’s exact test. PT20210: Prothrombin 20210.

Citation: Maharshak N, Halfon P, Deutsch V, Peretz H, Berliner S, Fishman S, Zelber-Sagi S, Rozovski U, Leshno M, Oren R. Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation. World J Gastroenterol 2011; 17(45): 5007-5013
URL: https://www.wjgnet.com/1007-9327/full/v17/i45/5007.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i45.5007