Plasma DNA methylation of Wnt antagonists predicts recurrence of esophageal squamous cell carcinoma

Table 3 Correlation between methylation and recurrence in esophageal squamous cell carcinoma patients

Gene	n	Recurrence		Crude OR (95% CI)	Pvalue	Adjusted OR1 (95% CI)	P value1
		No	Yes
SFRP-1
Negative	57	49	8	1.00	< 0.001	1.00	< 0.001
Positive	24	11	13	7.24 (2.42-21.68)		10.8 (2.54-46)
WIF-1
Negative	52	42	10	1.00	0.069	1.00	0.107
Positive	29	18	11	2.57 (0.93-7.11)		2.61 (0.8-8.47)
DKK-3
Negative	51	44	7	1.00	0.001	1.00	0.003
Positive	30	16	14	5.50 (1.88-16.08)		6.07 (1.73-21.28)
RUNX-3
Negative	52	45	7	1.00	< 0.001	1.00	0.001
Positive	29	15	14	6.00 (2.04-17.65)		7.81 (2.30-47)

¹Adjusted for age, gender, smoking, drinking, stage, surgical operation and chemo-/radio-therapy. CI: Confidence intervals; OR: Odds ratios.