Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma

Table 4 Univariate analysis of prognostic factors in the hepatocellular carcinoma group

Factors	Category	Number	P value1
Single marker
MnSOD (ng/mL)	< 110/≥ 110	22/8	0.01
TRX (ng/mL)	< 80/≥ 80	24/6	0.05
Age (yr)	< 70/≥ 70	12/18	0.23
Plt (× 104/μL)	< 10/≥ 10	19/11	0.38
PT (%)	< 80/≥ 80	15/15	0.02
Alb (g/dL)	< 3.5/≥ 3.5	15/15	0.02
T-Bil (mg/dL)	< 1.5/≥ 1.5	18/12	0.34
ALT (IU/L)	< 40/≥ 40	11/19	0.58
γ-GTP (IU/L)	< 50/≥ 50	17/13	0.98
AFP (ng/mL)	< 40/≥ 40	20/10	<0.01
DCP (mAU/mL)	< 40/≥ 40	16/14	0.02
Staging system
Child-Pugh stage	A/≥ B	16/14	< 0.01
CLIP score	0-1/≥ 2	22/8	0.01
JIS score	0-1/≥ 2	14/16	0.41

¹P values were assessed using the log-rank test. MnSOD: Manganese superoxide dismutase; TRX: Thioredoxin; Plt: Platelet count; PT: Prothrombin time; Alb: Albumin; T-Bil: Total bilirubin; ALT: Alanine aminotransferase; γ-GTP: γ-glutamyl transpeptidase; AFP: Alpha-fetoprotein; DCP: Serum des-γ-carboxy prothrombin; CLIP: Cancer of the Liver Italian Program; JIS: Japan Integrated Staging.