De novo combination therapy with lamivudine and adefovir dipivoxil in chronic hepatitis B patients

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 43

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

All Articles published online

Item

Count

PDF

299

HTML

2373

Figures (1-1)

156

Tables (1-3)

141

Sum=2969

Nov 21, 2011 (publication date) through Apr 24, 2024

Times Cited of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Brief Article

World J Gastroenterol. Nov 21, 2011; 17(43): 4804-4809
Published online Nov 21, 2011. doi: 10.3748/wjg.v17.i43.4804

Table 2 Biochemical responses of the patients, median (min-max)

	De novo combination group (n = 10)					Add-on combination group (n = 20)
	2 wk before combination treatment	4 wk after combination treatment	12 wk after combination treatment	24 wk aftercombinationtreatment	48 wk after combination treatment	2 wk before combination treatment	4 wk after combination treatment	12 wk after combination treatment	24 wk after combination treatment	48 wk after combination treatment
Child-Pugh score	11 (9-13)	10 (8-12)	10 (8-12)	9 (7-11)^c	7 (6-9)^c^a	11 (9-13)	10 (9-12)	10 (9-12)	10 (7-11)^c	9 (7-10)^c
Serum ALT (IU/L)	124 (82-156)^a	111 (80-141)^a	109 (69-125)^a	89 (59-112)^c^a	49 (28-67)^c^a	283 (187-321)	251 (171-302)^c	218 (146-277)^c	173 (105-239)^c	105 (65-186)^c
Serum TBIL (μmol/L)	49.5 (23-72)^a	47.3 (25.0-70.1)^a	41.3 (25.5-63.0)^a	37.8 (22.5-57.4)^c^a	31.0 (22.0-41.0)^c^a	73.5 (49.0-99.6)	68.3 (44.5-88.7)	63.5 (35.8-79.0)^c	56.7 (32.0-72.3)^c	41.2(29.0-58.1)^c
Serum ALB (g/L)	29.75(25.40-34.00)^a	30.15(27.20-34.10)^a	30.55(27.60-33.00)^a	32.80(29.00-35.00)^c^a	34.00(30.00-37.00)^c^a	26.65(23.00-32.00)	28.20(25.60-32.90)	27.85(25.00-31.90)	28.75(25.50-33.00)^c	30.5(28.0-34.8)^c

^aP < 0.05 vs add-on combination group;

^cP < 0.05 vs 2 wk before combination treatment in the same group. ALT: Alanine aminotransferase; TBIL: Total bilirubin; ALB: Albumin.

Citation: Fan XH, Geng JZ, Wang LF, Zheng YY, Lu HY, Li J, Xu XY. De novo combination therapy with lamivudine and adefovir dipivoxil in chronic hepatitis B patients. World J Gastroenterol 2011; 17(43): 4804-4809
URL: https://www.wjgnet.com/1007-9327/full/v17/i43/4804.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i43.4804