"Liverscore" is predictive of both liver fibrosis and activity in chronic hepatitis C

Table 2 Univariate analysis for significant and minimal disease

	Significant1(n = 46)	Minimal(n = 52)	P value
Age (yr)	39.6 ± 11.4	32.9 ± 8.7	0.002
Gender			0.15
Male	28 (61)	24 (46)
Female	18 (39)	28 (56)
Bilirubin total (mg/dL)	0.62 ± 0.34	0.49 ± 0.30	0.04
Bilirubin direct (mg/dL)	0.21 ± 0.17	0.15 ± 0.08	0.04
ALT (U/L)	53.2 ± 39.2	32.60 ± 15.90	0.002
ALP (U/L)	80.4 ± 26.9	81.70 ± 32.30	0.78
GGT (U/L)	51.8 ± 47.2	23.80 ± 16.90	< 0.001
Haptoglobin (g/L)	1.05 ± 0.45	1.05 ± 0.49	0.99
A2M (g/L)	2.56 ± 0.64	2.24 ± 0.55	0.009
Apo-A1 (mg/dL)	96.85 ± 23.70	114.2 ± 29.80	0.002
Hydroxyproline (μmol/L)	9.7 ± 7.0	13.5 ± 9.30	0.03
Proline (μmol/L)	123.0 ± 78.10	144.2 ± 106.4	0.27
Hyaluronic acid (ng/mL)	100 ± 150	23.90 ± 16.40	0.001

¹Significant disease, A2, 3 or F2-4. Minimal disease, A0, 1 and F0, 1, Results are shown as mean ± SD or n (%). ALT: Alanine transaminase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transpeptidase; A2M: Alpha-2 macroglobulin; Apo-A1: Apolipoprotein A-1.