Nestin in gastrointestinal and other cancers: Effects on cells and tumor angiogenesis

Figure 3 Tumor angiogenesis and nestin. Tumor cells induce neovascular formation, known as tumor angiogenesis. Formation of the neovasculature leads to tumor aggressiveness through tumor cell proliferation, invasiveness, metastasis, and refractoriness to therapy. Nestin expression has been reported in tumor vessels, and nestin may be a new molecular target for tumor angiogenesis.