Nitric oxide-releasing aspirin but not conventional aspirin improves healing of experimental colitis

Figure 9 The area of colonic lesions and plasma levels of proinflammatory cytokines IL-1β and tumor necrosis factor-α on day 10 after induction of colitis in rats treated with aspirin or celecoxib with or without 16, 16 dm prostaglandin E₂ (5 μg/kg per day ig). Mean ± SE of 6-8 rats. ^aP < 0.02 vs vehicle (control); ^cP <0.02 vs vehicle-treated and aspirin (ASA)-treated groups; ^eP < 0.02 vs ASA and celecoxib groups without concurrent prostaglandin E₂ (PGE₂) administration. TNBS: Trinitrobenzenesulfonic acid; TNF: Tumor necrosis factor.