Nitric oxide-releasing aspirin but not conventional aspirin improves healing of experimental colitis

Figure 7 The effect of concurrent administration of nitric oxide scavenger 2-​(4-​carboxyphenyl)-​4,​5-​dihydro-​4,​4,​5,​5-​tetramethyl-​1H-​imidazolyl-​1-​oxy-​3-​oxide, monopotassium salt on the area of colonic damage and alterations in colonic blood flow in rats with trinitrobenzenesulfonic acid-induced colitis, treated with vehicle or nitric oxide-aspirin (80 mg/kg per day ig) on day 10. Mean ± SE of 6-8 rats. ^aP < 0.05 vs vehicle group (control); ^cP < 0.05 vs vehicle or nitric oxide-aspirin (NO-ASA) without 2-​(4-​carboxyphenyl)-​4,​5-​dihydro-​4,​4,​5,​5-​tetramethyl-​1H-​imidazolyl-​1-​oxy-​3-​oxide, monopotassium salt. TNBS: Trinitrobenzenesulfonic acid; CBF: Colonic blood flow.