Nitric oxide-releasing aspirin but not conventional aspirin improves healing of experimental colitis

Table 3 The generation of prostaglandin E₂ in intact rats and those treated rats (mean ± SE)

Group	PGE2 generation in the colonic mucosa (pg/mg tissue weight)
Intact	182 ± 15.4
Vehicle	409 ± 23.2a
ASA (80 mg/kg per day)	130 ± 11.7c
Indomethacin (5 mg/kg per day)	124 ± 17.8c
SC-560 (5 mg/kg per day)	145 ± 15.6c
Celecoxib (10 mg/kg per day)	191 ± 18.3e
NO-ASA (80 mg/kg per day)	175 ± 17.3e

PGE₂: Prostaglandin E₂; ASA: Aspirin; SC-560: 5-​(4-​chlorophenyl)-​1-​(4-​methoxyphenyl)-​3-​(trifluoromethyl)-​1H-​pyrazole; NO: Nitric oxide.

^aP < 0.05 vs intact colonic mucosa;

^cP < 0.05 vs vehicle (control);

^eP < 0.05 vs ASA, indomethacin and SC-560 groups.