Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution

Figure 3 Restitution of rat intestinal epithelial cells around an artificially created wound in control and rebamipide-treated groups. A: Restitution of rat intestinal epithelial (RIE) cells was evaluated using a wound assay. The denuded area of RIE cells recovered in a time-dependent manner after wound induction. Restitution of the denuded area was promoted by rebamipide at 12 h after wound induction. B: To investigate the effects of rebamipide on RIE cell migration, cells were co-incubated with 2 mmol/L rebamipide after wound induction. Wound repair in 2 mmol/L rebamipide-treated cells occurred significantly earlier than it did in the controls. Datas represent the mean ± SE of four experiments. ^aP < 0.05 vs controls.