Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution

Figure 2 Effects of 1% rebamipide on histological findings in the colon on day 14 after trinitrobenzene sulfonic acid-induced injury. A: Histological appearance of colonic tissue in sham-operated rats (a), trinitrobenzene sulfonic acid (TNBS)-colitis rats (b), and TNBS-colitis rats treated with 1% rebamipide (c). Histological examination revealed that TNBS administration induced marked thickening of the colonic wall, which was associated with transmural infiltration of inflammatory cells. In contrast, both mural wall thickening and infiltration of inflammatory cells were inhibited in rats treated with 1% rebamipide. Hematoxylin and eosin staining (× 40). B: Histological score was evaluated. Data represent the mean ± SE of six rats. ^dP < 0.01 vs TNBS-colitis rats receiving the vehicle.