Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution

Figure 1 Effects of 1% rebamipide on macroscopic findings, mucosal damage score, and wet colon weight on day 14 after trinitrobenzene sulfonic acid-induced injury. A: Severe colitis was induced with hyperemia, edema, thickening, ulceration, and necrosis in trinitrobenzene sulfonic acid (TNBS)-colitis rats (b) compared to sham-operated rats (a). These changes were reduced in rats treated with 1% rebamipide (TNBS-colitis rats treated with 1% rebamipide) (c). B: A 1% rebamipide enema was administrated twice daily starting on day 7 after induction of colitis, until day 14. Rats were sacrificed on day 14, and the mucosal damage score was evaluated. Data are expressed as a scatter plot. ^dP < 0.01 vs sham-treated rats. ^eP < 0.05 vs TNBS-induced colitis rats receiving the vehicle. C: Rats were sacrificed on day 14 and the distal colon was removed, after which, the wet colon weight was immediately measured. Data represent the mean ± SE of seven rats. ^dP < 0.01 vs sham-treated rats receiving the vehicle. ^eP < 0.01 vs TNBS-induced colitis rats receiving the vehicle.