Bimodal visualization of colorectal uptake of nanoparticles in dimethylhydrazine-treated mice

Figure 3 Magnetic resonance and fluorescent images of 1,2-dimethylhydrazine impaired colorectal wall. A: Axial fluid attenuated inversion recovery (FLAIR) image 5 min after gadopentetate dimeglumine (Gd-DTPA) and fluorescein isothiocyanate (FITC)-loaded solid lipid nanoparticle enema. No mural enhancement was identified. Note the bladder Gd-DTPA deposition (top right: pre-enema FLAIR image ); B, C: Hematoxylin and eosin image of the same slice; nuclear atypia identified; B: × 40; C: × 400. D: Laser-scanning confocal fluorescence microscope image of the post-enema colorectal wall, showing the linear extracellular FITC deposition along the mucosa.