Liver function alterations after laparoscopy-assisted gastrectomy for gastric cancer and its clinical significance

Table 2 Preoperative and postoperative liver enzymes (mean ± SD)

Variables	Stomach cancer (n = 215)			Colon cancer (n = 121)
	LAG (n = 91)	OG (n = 124)	P1	LAC (n = 43)	OC (n = 78)	P2
AST (IU/L)
Preoperative	22.1 ± 7.6	21.8 ± 7.3	NS	20.8 ± 8.7	19.9 ± 6.3	NS
POD1	73.8 ± 67.2a	57.6 ± 45.9a	0.047	23.2 ± 11.8	22.2 ± 11.5	NS
POD3	41.1 ± 43.5a	38.4 ± 24.3a	NS	22.9 ± 9.5	22.4 ± 8.4	NS
POD5	28.9 ± 24.1a	29.5 ± 18.1a	NS	25.3 ± 10.8	22.3 ± 10.8	NS
POD7	24.0 ± 11.6	22.2 ± 11.3	NS	28.9 ± 26.2	24.7 ± 13.4	NS
ALT (IU/L)
Preoperative	23.9 ± 13.5	23.8 ± 15.8	NS	24.1 ± 3.7	17.0 ± 2.6	0.045
POD1	89.1 ± 103.7a	63.3 ± 65.9a	0.039	18.4 ± 8.1	17.4 ± 15.0	NS
POD3	62.2 ± 97.3a	51.5 ± 57.6a	NS	16.6 ± 6.5	15.9 ± 9.6	NS
POD5	43.2 ± 49.1a	39.4 ± 40.6a	NS	20.6 ± 13.9	16.4 ± 8.5	NS
POD7	33.7 ± 25.4	26.9 ± 17.9	0.033	32.1 ± 43.8	21.0 ± 25.4	NS
Total bilirubin (mg/dL)
Preoperative	0.6 ± 0.2	0.5 ± 0.3	NS	0.5 ± 0.2	0.5 ± 0.3	NS
POD1	0.8 ± 0.3	0.7 ± 0.3	NS	0.7 ± 0.4	0.6 ± 0.3	NS
POD3	0.8 ± 0.4	0.7 ± 0.5	NS	0.4 ± 0.2	0.4 ± 0.2	NS
POD5	0.7 ± 0.3	0.6 ± 0.3	NS	0.5 ± 0.2	0.4 ± 0.2	NS
POD7	0.7 ± 0.3	0.5 ± 0.2	NS	0.5 ± 0.2	0.4 ± 0.2	NS
ALP (IU/L)
Preoperative	65.6 ± 17.6	65.8 ± 22.1	NS	69.1 ± 20.3	64.4 ± 22.2	NS
POD1	46.7 ± 11.9	47.8 ± 14.6	NS	49.9 ± 15.5	44.6 ± 13.3	NS
POD3	44.2 ± 10.5	45.8 ± 14.5	NS	44.1 ± 11.7	41.9 ± 10.2	NS
POD5	50.6 ± 23.5	48.6 ± 15.6	NS	47.5 ± 18.7	43.2 ± 11.3	NS
POD7	57.9 ± 38.3	54.7 ± 22.6	NS	51.1 ± 24.1	47.2 ± 13.1	NS

¹P values represent the statistical difference between the laparoscopy-assisted gastrectomy (LAG) and open gastrectomy (OG) groups; ²P values represent the statistical difference between the laparoscopy-assisted colectomy (LAC) and open colectomy (OC) groups;

^aP < 0.05 vs preoperative liver enzymes using the paired t-test. POD: Postoperative day; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; NS: Not significant.