Late SV40 factor: A key mediator of Notch signaling in human hepatocarcinogenesis

Figure 7 Overexpression of exogenous late SV40 factor increases the growth of HepG2 tumors in vivo. A: 2 × 10⁶ cells were transfected with the late SV40 factor (LSF)-pEGFP-C₁ recombinant vector or the empty vector and injected into nude mice (n = 8). Representative picture of nude mice injected with LSF-pEGFP-C₁/HepG2 cells and pEGFP-C₁/HepG2 cells (arrow) at week 5; B: The mean tumor volume ± SE (mm³) within each group. The mean tumor volume in the LSF-pEGFP-C₁/HepG2 mice (P < 0.01) was significantly larger than that in the empty-vector group.