Late SV40 factor: A key mediator of Notch signaling in human hepatocarcinogenesis

Figure 1 Correlation between late SV40 factor overexpression and aberrant Notch-1 activation in liver cancer. Liver cancer tissue specimens from 25 patients were analyzed for Notch-1 and late SV40 factor (LSF) expression by immunochemistry. A: Representative sample showing the strong correlation between Notch-1 expression and LSF expression; A and B were labeled with Notch-1 antibody (magnification: A × 10 and B × 20); C and D were labeled with an anti-LSF antibody (magnification: C × 10 and D × 20); E: Liver cancer specimen stained with hematoxylin and eosin; F: Human normal liver tissue specimen labeled with Notch1 and LSF antibodies. Expression is negative (control).