Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism

Figure 1 Mice infected with Helicobacter pylori have reduced ghrelin expression and do not gain weight. C57BL6/J mice were infected with Helicobacter pylori (H. pylori) strain 67:21 [this strain is VacA+ and contains a complete genetically stable Cag pathogenicity island (PAI)]. While the control mice gained weight the infected mice did not (A). Mice infected with H. pylori had reduced ghrelin expression in the stomach (B) and reduced ghrelin plasma concentrations (C). ^aP < 0.05 vs control.