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Copyright ©2011 Baishideng Publishing Group Co.
World J Gastroenterol. May 28, 2011; 17(20): 2456-2464
Published online May 28, 2011. doi: 10.3748/wjg.v17.i20.2456
Table 1 Histone modifications, enzymes and genes
ModificationsEnzymesTarget gene transcription
Acetylation
H3GNATActivating
H4MYSTActivating
H3 and H4CBP/p300Activating
Deacetylation
H3 and H4HDACs 1-11Silencing
Methylation
H3K4Set1Activating
H3K36Set2Activating
H3K79DoT1LActivating
H3K27EZH2Silencing
H3K9SUV39H1Silencing
H4K20SUV4-20H1Silencing
Phosphorylation
H3S10RSK2Silencing
Methylated CpGDNMT1, DNMT3a-3bSilencing