Trefoil factors: Tumor progression markers and mitogens via EGFR/MAPK activation in cholangiocarcinoma

Figure 6 Trefoil factor 2 drives proliferation of KMBC cholangiocarcinoma cells via epidermal growth factor receptor tyrosine kinase and mitogen-activated protein kinase pathway activation. A: Proliferation of KMBC human cholangiocarcinoma cells determined by viable cell number counting with recombinant human trefoil factor (rhTFF)2 dose response (5, 50, 500 μg/mL) and epidermal growth factor (EGF) (5, 25, 50 ng/mL). Histograms show mean cell number per well. Error bars show standard error of the mean (SE). ^aP < 0.05; B: Proliferation of KMBC cells determined by viable cell number counting following treatment with combinations of