Trefoil factors: Tumor progression markers and mitogens via EGFR/MAPK activation in cholangiocarcinoma

Figure 2 Immunohistochemical detection of trefoil factor proteins in normal and dysplasia bile ducts (Original magnification × 400). A: Small and large normal bile ducts (short arrows) showing no trefoil factor (TFF)1 expression, whereas dysplasia showed moderately increased expression (long arrows); B: TFF2 expression was strongly positive in peribiliary glands (long arrows) but rarely present in dysplasia (short arrows); C: TFF3 was distributed widely at low level in small and large normal bile ducts (short arrows) and markedly increased in dysplasia (long arrows).