Survivin isoforms and clinicopathological characteristics in colorectal adenocarcinomas using real-time qPCR

Table 6 Association of mRNA expression survivin splice variants with clinicopathological characteristics in 52 patients suffering from colorectal cancer (mean ± SD)

Clinical characteristics	n	Wild-sur (copies/μL)	P value wild-sur	Sur-2b (copies/μL)	P value sur-2b	Sur-ΔEx3 (copies/μL)	P value sur-ΔEx3	Sur-2b/wildsur (copies/μL)	P value sur-2b/wildsur	Sur-ΔEx3/wildsur (copies/μL)	P value sur-ΔEx3/wildsur
Gender			0.978		0.685		0.631		0.570		0.387
Male	20	1216.1 ± 3438.6		98.0 ± 299.7		834.8 ± 3085.6		0.08 ± 0.09		0.47 ± 0.39
Female	32	589.5 ± 1259.1		31.1 ± 33.2		85.3 ± 117.1		0.17 ± 0.24		0.36 ± 0,41
Tumor size			0.088		0.438		0.869		0.544		0.097
≤ 5 cm	32	308.4 ± 491.3		28.6 ± 34.6		96.2 ± 116.1		0.17 ± 0.24		0.48 ± 0.41
> 5 cm	17	1949.4 ± 3956.2		119.3 ± 330.9		1055.8 ± 3531.9		0.09 ± 0.09		0.23 ± 0.24
Dukes stage			0.469		0.737		0.544		0.351		0.097
A	8	212.4 ± 403.4		27.7 ± 27.7		51.7 ± 66.1		0.37 ± 0.40		0.44 ± 0.35
B	11	476.9 ± 743.4		30.8 ± 45.8		137.7 ± 185.7		0.08 ± 0.12		0.37 ± 0.37
C	22	1556.8 ± 3533.1		95.4 ± 292.5		782.6 ± 3019.7		0.09 ± 0.10		0.30 ± 0.39
D	8	226.7 ± 146.7		35.6 ± 32.9		120.7 ± 66.5		0.15 ± 0.15		0.63 ± 0.35
T			0.006		0.125		0.041		0.103		0.492
0-2	8	212.4 ± 403.4		27.7 ± 27.7		51.7 ± 66.1		0.37 ± 0.40		0.44 ± 0.35
3	29	340.0 ± 521.1		26.5 ± 35.4		92.9 ± 127.2		0.10 ± 0.13		0.39 ± 0.37
4	12	2620.8 ± 4579.4		162.9 ± 389.8		1413.2 ± 4056.1		0.10 ± 0.08		0.40 ± 0.44
Histologic type			0.584		0.030		0.731		0.061		0.892
Polypoid (ecblastetic)	28	520.1 ± 1006.4		45.7 ± 56.2		141.2 ± 313.7		0.19 ± 0.25		0.31 ± 0.25
Ulcerous	21	1354.5 ± 3550.4		79.3 ± 298.5		769.5 ± 3083.3		0.06 ± 0.06		0.54 ± 0.51