Proton pump inhibitor step-down therapy for GERD: A multi-center study in Japan

Table 2 Population characteristics of study 2 n (%)

Characteristic	ITT population(n = 83)
Gender
Male/female	50 (60.2)/33 (39.8)
Age (yr)
Range	25-88
Median	64
BMI (kg/m2)
≤ 24.9 (normal or below normal)	60 (72.3)
25-29.9 (overweight)	20 (24.1)
≥ 30 (obese)	3 (3.6)
Previous treatment for GERD	27 (32.5)
Duration of GERD symptoms before initial treatment (mo)
< 1	14 (16.9)
1-11	42 (50.6)
≥ 12	27 (32.5)
Tobacco use	21 (25.3)
Alcohol use	39 (47.0)
Helicobacter pylori infection	27 (32.5)
The modified Los Angeles Classification
N/M	15 (18.1)/9 (10.8)
A/B	24 (28.9)/30 (36.1)
C/D	3 (3.6)/2 (2.4)
Atrophic gastritis1	15 (18.1)
Hiatus hernia	44 (53.0)
Ischemic heart disease	8 (9.6)
Diabetes mellitus	7 (8.4)
Bronchial asthma	3 (3.6)
GERD symptom before step-down
Complete remission	55 (66.3)
Partial remission	28 (33.7)

¹Atrophic gastritis was defined as only the O-type of the Kimura-Takemoto classification[20]. BMI: Body mass index; GERD: Gastroesophageal reflux disease; ITT: Intention-to-treat.